June 28, 2017

ASIAN PERSUASIONS 2: SAMURAI And CYBORGS – Rashomon, Azumi, Cyborg Girl, Red Sun + More [Weekend Entertainment] T.D.P. Enjoy :)

cyborg girl 17a637499

RASHOMON

Rashomon (Akira Kurosawa 1950 Engl Subs)

A priest, a woodcutter and another man are taking refuge from a rainstorm in the shell of a former gatehouse called Rashômon. The priest and the woodcutter are recounting the story of a murdered samurai whose body the woodcutter discovered three days earlier in a forest grove.

Both were summoned to testify at the murder trial, the priest who ran into the samurai and his wife traveling through the forest just before the murder occurred.

Three other people who testified at the trial are supposedly the only direct witnesses: a notorious bandit named Tajômaru, who allegedly murdered the samurai and raped his wife; the white veil cloaked wife of the samurai; and the samurai himself who testifies through the use of a medium.

The three tell a similarly structured story – that Tajômaru kidnapped and bound the samurai so that he could rape the wife – but which ultimately contradict each other, the motivations and the actual killing being what differ. The woodcutter reveals at Rashômon that he …

REVIEW:

As oppose to its commonplace plot, Rashomon as a concept is extraordinarily idiosyncratic and perhaps it is this striking attribute that makes it an undisputed masterpiece, howsoever improbable. It vividly limns the artistry of contrivance innate in the human psyche owing to the importunate desire of humans to placate their insatiable egos.

This manipulation of facts has no limits and entirely depends upon the skill of imaginative improvisation of the individual along with his level of comfort at skullduggery. The ability to misinterpret comes naturally to the humans as a desperate ploy to counter the adversities of life and that’s what makes it indispensable. As a direct consequence of contrivance, the concept of truth no longer remains universal but becomes rather subjective and a matter of individualistic perception.

Rashomon pioneered Kurosawa’s dream tryst with perpetual brilliance and undoubtedly played a pivotal part in making his name a mark of excellence in the world of cinema. Rashomon is a well knitted tale about a supercilious samurai, his whimsical wife and a boorish bandit. The bandit inveigles the samurai into imprisonment and has his way with samurai’s wife. The dead body of the samurai is later discovered under mysterious circumstances by a woodcutter.

The bandit is captured and arraigned along with the deranged widow of the samurai. Their narrated versions seem such contrasting that a psychic is called upon to conjure up the dead samurai’s spirit to record his testimony in order to corroborate the facts that seemed excessively manipulated. The samurai’s version yet again differs considerably from the testimonies of the other two. Each version though different seemed to satiate the respective ego of the testifier.

The woodcutter, who didn’t want to get involved personally, later confesses to a priest to have actually witnessed the incident and comes up with a version of his own which falsifies the other three. The movie is ingenious as its actual motive has nothing to do with the revelation of truth as verity is merely a matter of lame perception, but rather is to highlight the discrepancies among the different versions as a medium to depict the irrational complexities associated with the human psyche.

The concept of Rashomon though well ahead of its time, sowed the seeds for creative innovation in the world of cinema and has served as the undisputed benchmark of innovative excellence for well over five decades. A quintessential Kurosawa classic, strongly recommended to the masses for its sheer brilliance and enigmatic charm.

***
***


Azumi [ENG SUBS]


Azumi 2

In war-torn Japan, the Tokugawa Shogun, desperate to restore peace to his people, orders the assassination of the hostile warlords. A beautiful young woman is raised from birth with nine other orphans, to become an assassin. Her name is AZUMI, the ultimate assassin.

***
***

CYBORG GIRL

It is November 22, 2007. Jirou Kitamura (Keisuke Koide) is spending his 20th birthday alone. As he buys a birthday present for himself in a shopping mall, gathers attention of a ‘cute girl’ (Haruka Ayase) and she surprisingly smiles at him. Afterwards, she successfully steals a pair of clothes which is noticed by Jirou but he ignores the fact as she walks away in front of him and amazed to see her beauty. The mystery girl, who seems interested in him, follows him into the restaurant, where he was having spaghetti on the advice of her grandmother for a longer and peaceful life. She suddenly appears during which she states that it’s ‘her birthday too’. The two of them then exchange birthday presents. The girl, who seems unused to everything, behaves very boldly and suddenly rushes Jirou out of the restaurant without paying, provoking a chase through Tokyo. As he spends time with her, Jirou finds himself charmed by the girl. But after a few hours the girl insists she has to leave.

The story then jumps to one year later and Jirou is again celebrating his birthday alone in the same restaurant. All of a sudden, the same girl appears in front of him. This girl, however, has been sent to save him from a disastrous fate by a future version of himself- she’s a cyborg, modeled after the girl he met a year ago. While he was rejoiced by her presence. Suddenly, the restaurant was under attacked by a gunman but she saves him and others by throwing the gunman out of the window. Despite her ‘cute’ outward appearance, she is incredibly strong, and her behavior is erratic. Later on, in his home she reveals her true identity by showing him a 3D projection of his own future appearance as a more aged person who warns him about an upcoming disaster. Its comes to his knowledge that the bullet storm showdown at the restaurant caused him a lifelong paralysis. But, a lottery ticket he bought earlier was fortunate for him. Moreover, he spent all his time and money on one thing is to create her to save himself of the past about 60 years ago. Now, he has recreated the history of his timeline by sending her but it was not supposed to happen but it’ll correct itself by recaliberating to the right dimension. In a short span of time, she becomes Jirou’s protector as well as a loyal friend and they both share some wonderful moments. She also saves many other lives which happens to be a series of disappointing memories Jirou of the future regretted to witness them dying.

Over the time, Jirou not only becomes dependent on, but also falls for her. However, when she cannot return his feelings, he gets irritated and forbids her from seeing him unless she can do so. He begins to regret this, especially when it becomes apparent she is still helping him while staying out of sight. Another disaster soon happens: a gigantic earthquake completely devastates Tokyo. As his apartment block collapses, the girl appears to help him but even her inhuman strength isn’t enough to save him. After telling Jirou that she now understands his feelings, she is destroyed. Distraught, Jirou spends the next 61 years trying to rebuild her. He eventually succeeds, although he passes away soon afterwards.

Further in the future, 63 years later, in 2133, a girl is told there is a cyborg on display that looks just like her. She is curious, and buys the now defunct cyborg to experience the memories stored in her hard-drive. Intrigued, she then decides to fulfill her wish of going back in time to meet Jirou on his 20th birthday in 2007…

***

http://youtu.be/7t9qjWJo36I

AFTER THE RAIN

Ihei Misawa and his wife Tayo, stranded by rains at a country inn, bring a great deal of happiness to the other residents of the inn by means of Ihei’s generosity and good spirit.

Ihei is a masterless samurai and fencing expert. Ihei comes to the attention of Lord Shigeaki, who hires him as fencing instructor for Lord Shigeaki’s men. But Ihei’s expertise causes friction and jealousy in Shigeaki’s castle and his future there comes into doubt.

COMMENTS:

PhimMovies – I love the way the husband and wife treat one another. 🙂

Joe Caliber – is there a part 2 for this?
·
lawstermind – What an unexpected and wonderful experience. A truly remarkable film. Thank you.
·
thomiccor – GREAT MOVIE!

***
***

http://youtu.be/RytNui5iS2A

My Wife is a Gangster (korean/FULL movie)

junk903
Great movie!! It was great!!!

Ren Kurosakii
she was cuter without make up :3 thats what i think

Danielle
Like the movie

MsMusiclover95
There’s finally a movie where a woman can fight.

***
***


Appleseed (2004) English Dub
CGI Action Anime

*

BONUS

FISTS OF FURY – Bruce Lee

Chein is a city boy who moves with his cousins to work at a ice factory. He does this with a family promise never to get involved in any fight. However, when members of his family begin disappearing after meeting the management of the factor, the resulting mystery and pressures forces him to break that vow and take on the villainy of the Big Boss.

Not the best quality recording…but it is the ‘Real Original’ BRUCE LEE!

*

RED SUN

-Red Sun-Charles Bronson and Toshiro Mifune (1971)

The Japanese ambassador is traveling through the Wild West by train, when gangsters hold up the train, to rob a gold shipment. They also carry an ancient Japanese sword the ambassador was carrying as a present for the US president. The ambassador’s bodyguard (Toshiro Mifune) will go after them, with the aid of one of the gang’s leaders betrayed by his pals…

The story takes place in Arizona, around 1870. Link and Gotch are two ruthless robbers that attack along with their men at the train which carries the ambassador of Japan over to Washington. During the robbery, Gotch takes a very valuable gold sword, which is a gift from the emperor to the president of the U.S. and tries to kill Link, so that he can take all the money for himself.

Now Kuroda (the only survivor of the samurais that escorted the ambassador) and Link must leave their differences aside and work together. They both want to find Gotch, but for different reasons: Kuroda wants to take back the sword, and Link wants the stolen money. All this must be done in seven days, or the samurai will kill Link and himself.

*

http://youtu.be/xKRjGuocoBs
Shanghai Noon

Shanghai Noon: Jackie Chan plays a Chinese man who travels to the Wild West to rescue a kidnapped princess. After teaming up with a train robber, the unlikely duo takes on a Chinese traitor and his corrupt boss.

*

http://youtu.be/BAT6c4A3OoE

Shanghai Knights-ONE CD FULL LENGTH ENGLISH Comdey MOVIE
Jackie Chan

THIRD WORLD STRIKES BACK: Vaccine Workers Shot Dead – Tells Bill ‘Merchant Of Death’ Gates “We Don’t Want Your Vaccines Or Your Charity! Eat Lead!”

Bill "Merchant Of Death And Disease" Gates

Bill “Merchant Of Death And Disease” Gates

Bill Gates Continues ‘God’s Work’, Third World Vaccine Workers Shot Dead:

In January 2013, Bill Gates told the world in an interview that he had no need for money and that he believed the global vaccination program was God’s work. [1] “It’s not going to stop us succeeding,” says Gates. “It does force us to sit down with the Pakistan government to renew their commitments, see what they’re going to do in security and make changes to protect the women who are doing God’s work and getting out to these children and delivering the vaccine.”

His words came after several vaccine workers administering the polio vaccination in Pakistan were shot dead in January. [2]

It appears that although Gates wants to carry on with what he calls ‘God’s work,’ people living in the third world are beginning to make their feelings abundantly clear. It appears that they don’t want his vaccines or his charity, as more shootings were reported in Nigeria.

On February 8, 2013, The Guardian reported that at least nine health workers administering the polio vaccinations in Nigeria were shot dead by gunmen thought to belong to radical an Islamist sect. The Guardian wrote:

“The killings drew comparisons with a series of incidents in Pakistan last December where five female polio vaccinators were gunned down, apparently by Islamist militants. It also signalled a fresh wave of hostility towards immunisation drives in Nigeria, where some clerics have claimed the vaccines are part of a western plot to sterilise young girls and eliminate the Muslim population.” [3]

*** DO YOU KNOW WHAT’S IN THAT NEEDLE?

They are right to be suspicious because it would not be the first time that vaccines were given with the intention of sterilizing women in the third world. In 1995, many third world countries were given a tetanus vaccine containing a birth control drug by the World Health Organization.

An organization known as The Comite became suspicious of the protocols surrounding the vaccines and obtained several vials for testing. It was discovered that some of the vials contained human chorionic gonadotrophin (hCG), a naturally occurring hormone essential for maintaining a pregnancy.

However, when combined with a tetanus toxoid carrier, this vaccine essentially causes a woman’s body to produce antibodies against pregnancy, forcing her body to abort her unborn baby, as reported by ThinkTwice Global Vaccine Institute:

“In nature the hCG hormone alerts the woman’s body that she is pregnant and causes the release of other hormones to prepare the uterine lining for the implantation of the fertilized egg. The rapid rise in hCG levels after conception makes it an excellent marker for confirmation of pregnancy: when a woman takes a pregnancy test she is not tested for the pregnancy itself, but for the elevated presence of hCG.

However, when introduced into the body coupled with a tetanus toxoid carrier, antibodies will be formed not only against tetanus but also against hCG. In this case the body fails to recognize hCG as a friend and will produce anti-hCG antibodies. The antibodies will attack subsequent pregnancies by killing the hCG which naturally sustains a pregnancy; when a woman has sufficient anti-hCG antibodies in her system, she is rendered incapable of maintaining a pregnancy.” [4]

Curiously, no men, boys or babies were vaccinated during the program. The only people vaccinated with this particular vaccine were women aged between 15 and 45. Was it a coincidence that these vaccines were only given to women of childbearing age? After all, anyone can contract tetanus, can’t they?

*** THE ADVERSE EVENT YOU MIGHT NOT EXPECT

Polio vaccine workers are not the only health workers who have been attacked during the last few months. In December 2012, La Voix reported that parents of vaccine-damaged children in Chad, Northern Africa, took out their anger and frustration by torching a car belonging to a hospital worker. [5]

VacTruth has since been informed by Chadian contacts that the people of Chad are boycotting all vaccinations, while the parents of the vaccine damaged children stoned the school’s headmaster who had forced pupils to take the MenAfriVac Meningitis A vaccine. The parents have since announced that they have no choice but to take government and its international organizations to court.

This is probably because whether Gates believes he is doing ‘God’s work’ or not, dumping severely vaccine damaged children in a remote village in Africa without a doctor on site is almost certainly not God’s work and this is exactly what Gates has allowed to happen to the children adversely affected by the MenAfriVac Meningitis A vaccine.

Over the last few months I have written four articles covering recent events in Chad, Northern Africa, where 106 children became ill after receiving the meningitis vaccine, 40 of which were left paralyzed and suffering from convulsions. [6,7,8,9]

This week, VacTruth received word from a Chadian contact that said:

“Last night the Chadian minister of health evacuated all children paralyzed from MenAfriVac meningitis A vaccine, including very ill children, to Faya. I have just spoken to one person, who told me that seven girls and a boy are seriously ill with convulsions.

Please, help us. This forced evacuation of very ill and paralyzed children on a military plan, to a destination where there is not even basic medical personnel and equipment, is deliberately sending vulnerable children to a place where they are likely to die.”

Faya is a small town surrounded by desert at least 100 miles away from the children’s home village of Gouro. This is extremely worrying, especially after VacTruth received several medical records confirming that these children did indeed suffer vaccine injuries.

*** MEDICAL RECORDS AS EVIDENCE

Over the past three months, members of the community of Gouro have reached out to VacTruth with desperate pleas for assistance as they helplessly watch their children suffer. We received a copy of one of the children’s medical records from their parent, which was written in French and translated on our behalf by Desiree Rover, an activist and avid campaigner from the Netherlands.

According to the record of treatment, the child was admitted to the hospital for an “undesirable post-vaccinal manifestation” and “intoxication by meningitis A vaccine.” Over the course of the hospital stay, the child suffered from headaches, shaking, vomiting, intense abdominal pain, and “contractions,” which likely refers to seizures.

Sadly, this child was prescribed Largactil, a psychiatric drug used to treat schizophrenia, probably due to the fact that members of the government have insisted that the paralyzed children’s afflictions were all in their heads. There is no mention in the clinical records of any prescription or treatment for pain relief or seizures.

This medical record, as well as the others sent to VacTruth by parents, demonstrates that these children need continued medical care. Yet, the ill children have been returned to an isolated, poorly equipped village far from sufficient available help!

It has since been reported by Ecoterra International that the conditions of at least ten children have deteriorated since being evacuated. [10]

*** POLIO RATES SKYROCKET IN THE MIDST OF VACCINATION CAMPAIGNS

As if the poorest regions of Africa has not had enough problems, GlaxoSmithKline has decided that they would get in on the act. Ethan A. Huff from Natural News reported on Feburary 19, 2013, that GlaxoSmithKline has teamed up with the company Biological E Ltd. and together they have decided that is a great idea to give the children of Africa a six-in-one vaccine. This is a single-dose vaccine for polio, diphtheria, tetanus, whooping cough (pertussis), hepatitis B, and Haemophilus influenzae type B.

This vaccine will be specifically designed for the poorest children of world. Natural News says:

“According to reports, GSK will add the contents of its injectable polio shot to a pentavalent vaccine already being manufactured by Biological E Ltd. that contains the other five vaccines. Together, as part of a 50-50 joint venture, the two companies will manufacture the hexavalent vaccine, which will rival similar combination vaccines for polio currently being developed and administered by rival drug companies in India such as Serum Institute of India Ltd. and Sanofi Pasteur.” [11]

According to Natural News, a study published in the Indian Journal of Medical Ethics (IJME) found that cases of polio-related paralysis have skyrocketed as a result of widespread polio vaccine campaigns throughout India, which means the populations of India are not benefiting from existing polio vaccines as the vaccine industry claims they are. So the two companies decided to put their heads together and come up with a new vaccine to boost their own economy.

In other words if at first you do not succeed, try, try, try again!

Dr. Rebecca Carley made her feelings abundantly clear about vaccines being used as bioweapons in an article recently, while the resulting damage is hidden from the public. She wrote:

“As I continue to follow the ongoing vaccine induced genocide of the indigenous Tibu children in Chad, Africa, it has become obvious that the totality of the documents I have accrued over the years has now reached critical mass for the purpose of going on the offensive against the psychopaths orchestrating the depopulation agenda. This was the topic of my RBN show on 2/10/13; you can access the archive for free by going to http://thelightofdayradioshow.com/archives/RBN-BACKUP/New-RBN-Dr-Carley-Archives.html. [12]

Dr. Carley is right, as there is no better way of covering up adverse events than dumping sick children in the middle of nowhere and leaving them to die, is there? The saying ‘out of sight, out of mind’ springs to mind.

*** CONCLUSION

It appears that Mr. Gates will go to any lengths to vaccinate the world, even if the world makes it very clear that they do not want his vaccines. Rather than vaccinating more children, if he was such a humanitarian, why has he allowed vulnerable, sick children to be dumped in the middle of nowhere to die? Surely the world would applaud him far more loudly if he spent his millions making sure that any vaccine casualties were sufficiently cared for.

Feb 26th, 2013 | By Christina England

***

References

1. http://www.telegraph.co.uk/technology/bill-gates/9812672/…
2. http://www.guardian.co.uk/world/2012/dec/18/polio…
3. http://www.guardian.co.uk/world/2013/feb/08/gunmen-nigeria-kill-polio-workers
4. http://thinktwice.com/birthcon.htm
5. http://www.tolerance.ca/Article.aspx?ID=157421&L=en
6. http://vactruth.com/2013/01/06/paralyzed-after-meningitis-vaccine/
7. http://vactruth.com/2013/01/13/children-paralyzed-by-vaccine/
8. http://vactruth.com/2013/01/25/paralyzed-symptoms-in-head/
9. http://vactruth.com/2013/02/12/vaccine-cover-up/
10. http://www.groundreport.com/World/Do-to-them-what-they-are…
11. http://www.naturalnews.com039160_glaxosmithkline_vaccines_developing…
12. http://thelightofdayradioshow.com/archives/RBN-BACKUP/…

***

christina england  _MG_5488_pp[1]

Christina England

Christina England is a UK journalist and an author with a Higher National Diploma in Journalism and Media. She is studying for a BA Hons degree in English Literature and Humanities.

Besides being a regular contributor to VacTruth.com, Christina writes for American Chronicle, Weekly Blitz, and Namaste Publishing UK on immunization safety and efficacy.

Christina’s main area of expertise is in researching the areas surrounding false allegations of child abuse, particularly when a child has suffered a vaccine injury. Her work is now read internationally and has been translated into many languages. Christina has been on many radio shows and she speaks at seminars worldwide.

Christina is the mother of two adult sons, both with ASD and complex learning and behavior problems.

She is co-author of Shaken Baby Syndrome or Vaccine Induced Encephalitis – Are Parents Being Falsely Accused?

Additionally, Christina is a contributing author in Voices of Autism: The Healing Companion: Stories for Courage, Comfort and Strength.

***
***


BILL GATES EXPOSING DEPOPULATION PLANS OF AGENDA 21 ON LIVE SHOW

“If we do a really good job with Vaccines, Healthcare, and Human Reproductive Services, we can lower the Human Population by 15%” – Vaccine Bill “The Merchant Of Death” Gates

***
***

COMMENTS:

Kimberly

If he cares so much why doesn’t send healthy, non-processed, non-gmo food? Wouldn’t good nutrition also be effective in helping them from getting sick? He seems fine with letting them starve or be malnourished but he makes sure to get those vaccines in them.

*

betsyan > Kimberly

The PhRma industry uses these downtrodden nations as “testing grounds”. Never mind that more than half of their population is sick and malnourished – what kind of results to their chemical concoctions should anyone trust? People who are ill are not supposed to be vaccinated until they’re well, so how much trust should anyone put in these “results”??
Now doctors are giving vax to anyone at anytime and almost anywhere you look. Grocery stores, malls, drugstores, big box stores – – – they are pushing these things as if they’re really GOOD for people!
Good book: Vaccination is NOT Immunization by Dr. Tim O’Shea, D.C.

On youtube there’s a video regarding polio that everyone should see (it’s only about 10 minutes long). Go to youtube.com and type into the search box: Dr. Maurice Hilleman. This is an excellent presentation to show to people who are either on the fence about vax or who believe they actually were designed to “help” people.

Thanks to Lowell for all those web sites. The more ammunition one has in this fight, the better. Has everyone taken the time (3 hours) to watch Marketing of Madness? If not, you should. It brings the whole world of medicine into focus, even though they’re main message has to do with psych drugs. Nevertheless, IMPHO, one class of drugs just spills over into the next. They are a FOR PROFIT business, never forget it. Bill Gates is in there throwing money around in order to make more money, that’s how it works. Doesn’t matter if the product is good, bad or indifferent, as long as makes a profit. I don’t understand why the general public can’t see this? But you know, if it’s on TV it must be the truth, right?
Well, when the SHTF we can say you were warned.

*

Lowell

Here is some added and related information and sources.

Just look at the insanity of the number of all these childhood vaccines and doses before the age of 6, on this recommended list by CDC. 5 shots in one well baby visit; and if they get behind, then how many? The reality of this situation is just near to mind boggling.

Put in your child’s birth date, and see exactly how many vaccinations there are.

Instant Childhood Immunization Schedule, (from the CDC)
http://www2a.cdc.gov/nip/kidst…

These are the vaccine ingredients, which for the most part have never been tested for safety; much more when when all those repeat vaccines are combined.

Vaccine Ingredients
http://www.novaccine.com/vacci…

Individual Vaccines
http://www.novaccine.com/speci…

Some more related information.

[ SOURCE ]

PARALYSIS HAUNTS ‘POLIO FREE’ INDIA: 30 Scientific Studies Showing Link Between Vaccines And Autism

Indian Child Getting Oral Polio Vaccine

Indian Child Getting Oral Polio Vaccine

In 1976 Dr. Jonas Salk, Creator of the 1950 Polio Vaccine testified that the live virus vaccine used almost exclusively in the United States from the 1960 t0 2000; “Was the principal if not the sole cause of all polio cases in the U.S. since 1961.”

India has a surge of children with paralysis. The causes are not hard to identify: the oral polio vaccine and redefinition of polio-induced paralysis to “acute flaccid paralysis”. The result of this fiasco is a plan to give non-live polio vaccines—and it comes at huge cost, negating the reason for using the oral vaccine.

Polio, often thought of as synonymous with paralysis and disability, has been given a new name in India. It is now known as AFP or acute flaccid paralysis. This and the fact that cases of polio caused by the oral polio vaccine (OPV) are not being reflected as polio have ensured that India is into its second year of “polio free” status. After this charade is maintained for one more year, India will be certified by the WHO as “polio free” and will be showcased as a success story of the Global Polio Eradication Initiative that was launched in 1988 by the World Health Assembly.

Smallpox was declared eradicated in 1980. According to medical researcher Professor William Muraskin, the experts involved in this exercise were looking for another opportunity to flaunt their skills. When they chose polio many eyebrows were raised. Polio was not on the priority radar of the countries where this exercise was to be launched. These developing nations were struggling to provide basic health needs. India, for example, is incapable of providing clean water, sanitation, hygiene, and nutrition for a majority of its population even 65 years after Independence. [Please see HEEALS for an on-the-ground organization in India dealing with this issue. –Editor]

Furthermore OPV was chosen to be the only weapon to eradicate polio. Dr T Jacob John pointed out that this vaccine, consisting of live viruses, is notorious for causing vaccine induced polio. Because those vaccinated tend to shed the virus in their stool, it can mutate into a virulent form, causing paralytic polio in others, even leading to polio epidemics.

Dr. Anant Phadke and C. Sathyamala argued that it is not possible to eradicate polio, a disease primarily of poor sanitation and nutrition, with a vaccine. Polio-like paralysis can also be caused caused by other factors. DDT and other pesticides, exposure to lead and arsenic, and vaccinations can trigger paralysis. Thus a holistic approach was needed to tackle the disease.

Medical textbooks reveal that exposure to polio viruses rarely results in paralysis. More than 95% of those exposed will show no symptoms at all. Of the rest, many will exhibit symptoms resembling a common cold, a few will suffer temporary lameness, and fewer than 1% will exhibit permanent paralysis. Exposure to the polio virus is actually the best immunity against viral polio. It offers permanent immunity to more than 99% exposed to it. According to Dr Yash Paul, those who become permanently paralyzed may have some inherent susceptibility that should be investigated.

Dr. Phadke pointed out that smallpox and polio eradication are two entirely different things. Polio viruses can infect children without causing any external symptoms and thus remain in circulation. He alleged that it was for the benefit of the developed nations, who could stop their vaccination programs once the wild polio virus was eradicated worldwide, and for the manufacturers, who were promoting the program because the OPV was discontinued in the developed countries due to its risks, that the polio eradication strategy was launched. This eradication effort, costing over 1.2 billion rupees, has broken the back of the Indian health system.

The National Polio Surveillance Project data show that the polio eradication program has increased paralysis among children—from 3,047 cases yearly in 1997 to 61,038 cases in 2012, most now being classified as AFP instead of polio. The Government does not reveal how many of these cases are due to the vaccine. It was observed in 2005 that, against 66 cases of polio caused by the wild polio virus that year, 1,645 were caused by the vaccine. Data reveals that those vaccinated are 6.26 times more likely to be paralyzed.

Many mutated virus strains are running loose in India. In Japan, after three months of use, 16 extremely virulent strains of the vaccine viruses and 78 strains in total were found in sewage and in its rivers. India has been using the vaccine since 1978, intensively since 1997, and one cannot even imagine how many virulent strains could be circulating in this country that is devoid of basic sewerage disposal and sanitation facilities.

Why are more than 60,000 children in India becoming paralyzed every year? Dr Neetu Vashisht has analyzed that the cases of AFP in India are directly proportionate to the number of doses of OPV given, implying a relationship. Taking into consideration the normal AFP rate, it has been deduced that in 2011, India has suffered 47,500 extra cases of paralysis. Studies have shown that death rates in children with AFP are twice as high as the death rate among children with polio paralysis.In Brazil, a study has implicated this vaccine in cases of Guillain Barré Syndrome, transverse myelitis, and facial palsy. Thus the claim of the Government that these cases of paralysis have no relation to the vaccine merits extensive investigation.

In April 2004 a memorandum was submitted to the WHO, UNICEF and the Government of India by Prof. Debabar Bannerjee and other eminent doctors pointing out that the WHO inflated 32,419 cases of polio to 350,000 to justify the program. The definition of polio has been changed repeatedly since the program was launched, thus automatically leading to a drastic fall in the number of cases. A significant number of children declared polio-affected by the polio virus were sufficiently vaccinated, and that children were being rendered paralytic directly due to the vaccine.

The memorandum also pointed out that polio eradication was not possible in India, as the vaccine viruses had mutated into virulent strains and were circulating. In August 2006, the Indian Medical Association reiterated the above and called for identifying the unfortunate victims and compensating them.

Today, throwing all caution to the wind, children are being given an unprecedented 50 doses of the vaccine and even those who should be medically exempt are being vaccinated. Dr Puliyel reveals that a synthetic version of the polio virus with a formula called ‘CHNOPS’ makes a mockery of the eradication effort.

Dr Pushpa Bhargava points out that polio was already on the decline even before the eradication effort began. Polio in India was concentrated in a few pockets of Uttar Pradesh and Bihar, which accounted for 96% of the cases reported. Improving sanitation and nutrition in these areas, along with routine rounds of the relatively safer inactivated polio vaccine (IPV), would have drastically reduced polio without taking resorting to the chicanery that has resulted in an unprecedented toll of disability in children in all parts of the country.

Hidden in the packet inserts of the OPV is an ominous statement saying that the vaccine has not been tested for causing cancer or infertility. The presence of untested monkey viruses, and phenol and polysorbate 80, both of which are endocrine disruptors, in the vaccine raises concerns. It is also known that the vaccine virus strains can lie latent in the body and cause polio decades after administration.

India is now preparing to launch the much costlier IPV all over the country, which will require money and trained manpower at a scale that it currently does not have, to counter the vaccine viruses in circulation. The wild polio viruses, which actually conferred immunity to children, are now no longer widely prevalent, leaving future children exposed to unexpected epidemics. The so called benefits of polio eradication have eluded this indebted country and its children face an uncertain future. It is important that lessons from this misadventure be learnt to oppose future assaults on the children of our country.

Editor’s Note: One must also ask how much these expenditures in vaccination have taken from true life and health preserving practices, such as bringing clean water and sanitation to people.

Jagannath Chatterjee works to create vaccine awareness in India. Please see Information on Vaccine Risks.

Read the full article here: http://gaia-health.com/gaia-blog/2013-03-28/paralysis-haunts-polio-free-india/

– Jagannath Chatterjee
Gaia-Health.com
March 28, 2013

[ SOURCE: Health Impact News ]

***

***

autism-to-one-in-88

Cleaning out my files and I found this document compiled by my friend Ginger Taylor. 30 studies that show a link between vaccines and autism. 30. 30. DO YOU UNDERSTAND? What you hear on TV, from the CDC, the IOM, the AAP and the NIH is nothing more than eisegesis. You want to know the real kicker? There are 49, I couldn’t fit them all in the note character range (on Facebook).

Evidence that vaccines can cause autism

It is an often repeated fallacy that there is no research that supports the supposition that vaccines can cause autism. This talking point is most often repeated by medical personnel and public health officials who have simply never been told that these studies exist, and in some cases by those who refuse to read the information when it is offered to them, so they continue to labor under the false assumption that vaccine autism causation is merely an “internet rumor” or a result of one paper that was published in 1998.

This untruth was again testified to during the HHS Committee hearings

In fact, the first research paper to offer evidence that vaccines may cause autism was THE first paper ever written on autism. In the 1930’s, Child Psychiatrist Leo Kanner discovered 11 children over the course of several years who displayed a novel set of neurological symptoms that had never been described in the medical literature, where children were withdrawn, uncommunicative and displayed similar odd behaviors. This disorder would become known as “autism.” In the paper, Dr. Kanner noted that onset of the disorder began following the administration of a small pox vaccine. This paper, was published in 1943, and evidence that vaccination causes an ever increasing rate of neurological and immunological regressions, including autism, has been mounting from that time until now.

Autistic Disturbances of Affective Contact

Leo Kanner, Johns Hopkins University, 1943

“Since 1938, there have come to our attention a number of children whose condition differs so markedly and uniquely from anything reported so far, that each case merits – and, I hope, will eventually receive – at detailed consideration of its fascinating peculiarities.”

All of Kanners cases were born after, and began to appear following, the introduction of Eli Lilly’s new form of water soluble mercury in the late 1920s used as an anti-fungal in forestry, a wood treatment product in the lumber industry and as a disinfectant and anti-bacterial in the medical industry under the name of “Thimerosal” that was included in vaccines.

For further information on the early evidence of a vaccine/connection, I recommend reading Dr. Bryan Jepson’s book, “Changing the Course of Autism: A Scientific Approach for Parents and Physicians,” as well as Mark Blaxill and Dan Olmseted’s new book “The Age of Autism: Mercury, Medicine, and a Man-made Epidemic.”

As I testified to at the hearing, there is abundant research supporting the vaccine autism link. I have included 49 research papers for your review, and only included research published in the last ten years or so. This is by no means a complete list, but it one that I have been compiling for the last few years as relevant research came to my attention. I have ONLY included autism related information, not research on other vaccine injuries of which there are many.

As you can see, the medical professionals testifying that there is no scientific support for the vaccine/autism causation theory are uninformed about the current state of the science. When vaccination decisions are made based on an uninformed opinion, it means serious potential damage to the patient, and because of the law preventing lawsuits for vaccine injury, it also means that the uninformed medical professionals making bad recommendations CANNOT be held accountable in any way for giving the patient bad information.

Parents want to know if their child can develop autism from their vaccines. If they believe that the answer is yes, and the risk of brain injury from vaccination is higher than their risk from a disease, it is their right to decline vaccination for themselves and their children with out coercion.

Patients MUST be able to make their own informed vaccine decisions, because often, they know more about potential vaccine risks that even top public health officials do.

*
(( 1. )) Hepatitis B Vaccination of Male Neonates and Autism

Annals of Epidemiology , Vol. 19, No. 9 ABSTRACTS (ACE), September 2009: 651-680,

p. 659

CM Gallagher, MS Goodman, Graduate Program in Public Health, Stony Brook University Medical Center, Stony Brook, NY

PURPOSE: Universal newborn immunization with hepatitis B vaccine was recommended in 1991; however, safety findings are mixed. The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events. Other studies found positive associations between

hepatitis B vaccination and ear infection, pharyngitis, and chronic arthritis; as well as receipt of early intervention/special education services (EIS); in probability samples of U.S. children. Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS. We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD.

METHODS: This cross-sectional study used U.S. probability samples obtained from National Health Interview Survey 1997-2002 datasets. Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3-17 years with shot records, adjusted for race, maternal education, and two-parent household.

RESULTS: Boys who received the hepatitis B vaccine during the first month of life had 2.94 greater odds for ASD (nZ31 of 7,486; OR Z 2.94; p Z 0.03; 95% CI Z 1.10, 7.90)

compared to later- or unvaccinated boys. Non-Hispanic white boys were 61% less likely to have ASD (ORZ0.39; pZ0.04; 95% CIZ0.16, 0.94) relative to non-white boys.

CONCLUSION: Findings suggest that U.S. male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD; risk was greatest for non-white boys.

*

(( 2. )) Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity

Toxicology and Applied Pharmacology, 2006

Robert Natafa, Corinne Skorupkab, Lorene Ametb, Alain Lama, Anthea Springbettc and Richard Lathed, aLaboratoire Philippe Auguste, Paris, France, Association ARIANE, Clichy, France, Department of Statistics, Roslin Institute, Roslin, UK, Pieta Research,

This new study from France utilizes a new and sophisticated measurement for environmental toxicity by assessing porphyrin levels in autistic children. It provides clear and unequivocal evidence that children with autism spectrum disorders are more toxic than their neurotypical peers.

Excerpt: “Coproporphyrin levels were elevated in children with autistic disorder relative to control groups…the elevation was significant. These data implicate environmental toxicity in childhood autistic disorder.”

Abstract: To address a possible environmental contribution to autism, we carried out a retrospective study on urinary porphyrin levels, a biomarker of environmental toxicity, in 269 children with neurodevelopmental and related disorders referred to a Paris clinic (2002–2004), including 106 with autistic disorder. Urinary porphyrin levels determined by high-performance liquid chromatography were compared between diagnostic groups including internal and external control groups. Coproporphyrin levels were elevated in children with autistic disorder relative to control groups. Elevation was maintained on normalization for age or to a control heme pathway metabolite (uroporphyrin) in the same samples. The elevation was significant (P < 0.001). Porphyrin levels were unchanged in Asperger’s disorder, distinguishing it from autistic disorder. The atypical molecule precoproporphyrin, a specific indicator of heavy metal toxicity, was also elevated in autistic disorder (P < 0.001) but not significantly in Asperger’s. A subgroup with autistic disorder was treated with oral dimercaptosuccinic acid (DMSA) with a view to heavy metal removal. Following DMSA there was a significant (P = 0.002) drop in urinary porphyrin excretion. These data implicate environmental toxicity in childhood autistic disorder. * (( 3. )) Theoretical aspects of autism: Causes—A review Journal of Immunotoxicology, January-March 2011, Vol. 8, No. 1 , Pages 68-79 Helen V. Ratajczak, PhD Autism, a member of the pervasive developmental disorders (PDDs), has been increasing dramatically since its description by Leo Kanner in 1943. First estimated to occur in 4 to 5 per 10,000 children, the incidence of autism is now 1 per 110 in the United States, and 1 per 64 in the United Kingdom, with similar incidences throughout the world. Searching information from 1943 to the present in PubMed and Ovid Medline databases, this review summarizes results that correlate the timing of changes in incidence with environmental changes. Autism could result from more than one cause, with different manifestations in different individuals that share common symptoms. Documented causes of autism include genetic mutations and/or deletions, viral infections, and encephalitis following vaccination. Therefore, autism is the result of genetic defects and/or inflammation of the brain. The inflammation could be caused by a defective placenta, immature blood-brain barrier, the immune response of the mother to infection while pregnant, a premature birth, encephalitis in the child after birth, or a toxic environment. * (( 4. )) Uncoupling of ATP-mediated Calcium Signaling and Dysregulated IL-6 Secretion in Dendritic Cells by Nanomolar Thimerosal Environmental Health Perspectives, July 2006. Samuel R. Goth, Ruth A. Chu Jeffrey P. Gregg This study demonstrates that very low-levels of Thimerosal can contribute to immune system disregulation. Excerpt: “Our findings that DCs primarily express the RyR1 channel complex and that this complex is uncoupled by very low levels of THI with dysregulated IL-6 secretion raise intriguing questions about a molecular basis for immune dyregulation and the possible role of the RyR1 complex in genetic susceptibility of the immune system to mercury.” Abstract Dendritic cells (DCs), a rare cell type widely distributed in the soma, are potent antigen presenting cells that initiate primary immune responses. DCs rely on intracellular redox state and calcium (Ca2+) signals for proper development and function, but the relationship between these two signaling systems is unclear. Thimerosal (THI) is a mercurial used to preserve vaccines, consumer products, and experimentally to induce Ca2+ release from microsomal stores. We tested ATP-mediated Ca2+ responses of DCs transiently exposed to nanomolar THI. Transcriptional and immunocytochemical analyses show murine myeloid immature and mature DC (IDCs, MDCs) express inositol 1, 4, 5-trisphosphate and ryanodine receptor (IP3R, RyR) Ca2+ channels, known targets of THI. IDCs express the RyR1 isoform in a punctate distribution that is densest near plasma membranes and within dendritic processes whereas IP3Rs are more generally distributed. RyR1 positively and negatively regulates purinergic signaling since ryanodine (Ry) blockade (1) recruited 80 percent more ATP responders, (2) shortened ATP-mediated Ca2+ transients >2-fold,

(3) and produced a delayed and persistent rise (≥2-fold) in baseline Ca2+. THI (100nM,

5min) recruited more ATP responders, shortened the ATP-mediated Ca2+ transient (≥1.4-

fold) and produced a delayed rise (≥3-fold) in the Ca2+ baseline, mimicking Ry. THI and

Ry, in combination, produced additive effects leading to uncoupling of IP3R and RyR1

signals. THI altered ATP-mediated IL-6 secretion, initially enhancing the rate of but

suppressing overall cytokine secretion in DCs. DCs are exquisitely sensitive to THI, with

one mechanism involving the uncoupling of positive and negative regulation of Ca2+

signals contributed by RyR1.

*

(( 5. )) Gender-selective toxicity of thimerosal.

Exp Toxicol Pathol. 2009 Mar;61(2):133-6. Epub 2008 Sep 3.

Branch DR, Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

Abstract

A recent report shows a correlation of the historical use of thimerosal in therapeutic immunizations with the subsequent development of autism; however, this association remains controversial. Autism occurs approximately four times more frequently in males compared to females; thus, studies of thimerosal toxicity should take into consideration gender-selective effects. The present study was originally undertaken to determine the maximum tolerated dose (MTD) of thimersosal in male and female CD1 mice. However, during the limited MTD studies, it became apparent that thimerosal has a differential MTD that depends on whether the mouse is male or female. At doses of 38.4-76.8mg/kg using 10% DMSO as diluent, seven of seven male mice compared to zero of seven female mice tested succumbed to thimerosal. Although the thimerosal levels used were very high, as we were originally only trying to determine MTD, it was completely unexpected to observe a difference of the MTD between male and female mice. Thus, our studies, although not directly addressing the controversy surrounding thimerosal and autism, and still preliminary due to small numbers of mice examined, provide, nevertheless, the first report of gender-selective toxicity of thimerosal and indicate that any future studies of thimerosal toxicity should take into consideration gender-specific differences.

*

(( 6. )) Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal

Environmental Health Perspectives, Aug 2005.

Thomas Burbacher, PhD [University of Washington].

This study demonstrates clearly and unequivocally that ethyl mercury, the kind of mercury found in vaccines, not only ends up in the brain, but leaves double the amount of inorganic mercury as methyl mercury, the kind of mercury found in fish. This work is groundbreaking because little is known about ethyl mercury, and many health authorities have asserted that the mercury found in vaccines is the “safe kind.” This study also delivers a strong rebuke of the Institute of Medicine’s recommendation in 2004 to no longer pursue the mercury-autism connection.

Excerpt: “A recently published IOM review (IOM 2004) appears to have abandoned the earlier recommendation [of studying mercury and autism] as well as back away from the American Academy of Pediatrics goal [of removing mercury from vaccines]. This approach is difficult to understand, given our current limited knowledge of the toxicokinetics and developmental neurotoxicity of thimerosal, a compound that has been (and will continue to be) injected in millions of newborns and infants.”

*

(( 7. )) Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure.

Toxicology and Applied Pharmacology, 1994

Charleston JS, Bolender RP, Mottet NK, Body RL, Vahter ME, Burbacher TM., Department of Pathology, School of Medicine, University of Washington

The number of neurons, astrocytes, reactive glia, oligodendrocytes, endothelia, and pericytes in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl mercury (MeHg) and mercuric chloride (inorganic mercury; IHg) has been estimated by use of the optical volume fractionator stereology technique. Four groups of monkeys were exposed to MeHg (50 micrograms Hg/kg body wt/day) by mouth for 6, 12, 18, and 12 months followed by 6 months without exposure (clearance group). A fifth group of monkeys was administered IHg (as HgCl2; 200 micrograms Hg/kg body wt/day) by constant rate intravenous infusion via an indwelling catheter for 3 months. Reactive glia showed a significant increase in number for every treatment group, increasing 72% in the 6-month, 152% in the 12-month, and 120% in the 18-month MeHg exposed groups, and the number of reactive glia in the clearance group remained elevated (89%). The IHg exposed group showed a 165% increase in the number of reactive glia. The IHg exposed group and the clearance group had low levels of MeHg present within the tissue; however, the level of IHg was elevated in both groups. These results suggest that the IHg may be responsible for the increase in reactive glia. All other cell types, including the neurons, showed no significant change in number at the prescribed exposure level and durations. The identities of the reactive glial cells and the implications for the long-term function and survivability of the neurons due to changes in the glial population following subclinical long-term exposure to mercury are discussed.

*

(( 8. )) Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism

Annals of Neurology, Feb 2005.

Diana L. Vargas, MD [Johns Hopkins University].

This study, performed independently and using a different methodology than Dr. Herbert (see above) reached the same conclusion: the brains of autistic children are suffering from inflammation.

Excerpt: “Because this neuroinflammatory process appears to be associated with an ongoing and chronic mechanism of CNS dysfunction, potential therapeutic interventions should focus on the control of its detrimental effects and thereby eventually modify the clinical course of autism.”

*

(( 9. )) Autism: A Brain Disorder, or A Disorder That Affects the Brain?

Clinical Neuropsychiatry, 2005

Martha R. Herbert M.D., Ph.D., Harvard University

Autism is defined behaviorally, as a syndrome of abnormalities involving language, social reciprocity and hyperfocus or reduced behavioral flexibility. It is clearly heterogeneous, and it can be accompanied by unusual talents as well as by impairments, but its underlying biological and genetic basis in unknown. Autism has been modeled as a brain-based, strongly genetic disorder, but emerging findings and hypotheses support a broader model of the condition as a genetically influenced and systemic. These include imaging, neuropathology and psychological evidence of pervasive (and not just specific) brain and phenotypic features; postnatal evolution and chronic persistence of brain, behavior and tissue changes (e.g. inflammation) and physical illness symptomatology (e.g. gastrointestinal, immune, recurrent infection); overlap with other disorders; and reports of rate increases and improvement or recovery that support a role for modulation of the condition by environmental factors (e.g. exacerbation or triggering by toxins, infectious agents, or others stressors, or improvement by treatment). Modeling autism more broadly encompasses previous work, but also encourages the expansion of research and treatment to include intermediary domains of molecular and cellular mechanisms, as well as chronic tissue, metabolic and somatic changes previously addressed only to a limited degree. The heterogeneous biologies underlying autism may conceivably converge onto the autism profile via multiple mechanisms on the one hand and processing and connectivity abnormalities on the other may illuminate relevant final common pathways and contribute to focusing on the search for treatment targets in this biologically and etiologically heterogeneous behavioral syndrome.

*

(( 10. )) Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and Thimerosal

Molecular Psychiatry, July 2004.

Richard C. Deth, PhD [Northeastern University].

This study demonstrates how Thimerosal inhibits methylation, a central driver of cellular communication and development. Excerpt:

“The potent inhibition of this pathway [methylation] by ethanol, lead, mercury, aluminum, and thimerosal suggests it may be an important target of neurodevelopmental toxins.”

*

(( 11. )) Validation of the Phenomenon of Autistic Regression Using Home Videotapes

Archives of General Psychiatry, 2005

Emily Werner, PhD; Geraldine Dawson, PhD, University of Washington

Objective To validate parental report of autistic regression using behavioral data coded from home videotapes of children with autism spectrum disorder (ASD) vs typical development taken at 12 and 24 months of age.

Design Home videotapes of 56 children’s first and second birthday parties were collected from parents of young children with ASD with and without a reported history of regression and typically developing children. Child behaviors were coded by raters blind to child diagnosis and regression history. A parent interview that elicited information about parents’ recall of early symptoms from birth was also administered.

Setting Participants were recruited from a multidisciplinary study of autism conducted at a major university.

Participants Fifteen children with ASD with a history of regression, 21 children with ASD with early-onset autism, and 20 typically developing children and their parents participated.

Main Outcome Measures Observations of children’s communicative, social, affective, repetitive behaviors, and toy play coded from videotapes of the toddlers’ first and second birthday parties.

Results Analyses revealed that infants with ASD with regression show similar use of joint attention and more frequent use of words and babble compared with typical infants at 12 months of age. In contrast, infants with ASD with early onset of symptoms and no regression displayed fewer joint attention and communicative behaviors at 12 months of age. By 24 months of age, both groups of toddlers with ASD displayed fewer instances of word use, vocalizations, declarative pointing, social gaze, and orienting to name as compared with typically developing 24-month-olds.

Parent interview data suggested that some children with regression displayed difficulties in regulatory behavior before the regression occurred.

Conclusion This study validates the existence of early autistic regression.

UPDATE: Since the Poling Case, this has become a popular link, so I will update it with more research and better information so that you can actually find and read the articles. Below is a partial list that I will keep adding to.

*

(( 12. )) Blood Levels of Mercury Are Related to Diagnosis of Autism: A Reanalysis of an Important Data Set

Journal of Child Neurology, Vol. 22, No. 11, 1308-1311 (2007)

M. Catherine DeSoto, PhD, Robert T. Hitlan, PhD -Department of Psychology, University of Northern Iowa, Cedar Falls, Iowa

Excerpt: “We have reanalyzed the data set originally reported by Ip et al. in 2004 and have found that the original p value was in error and that a significant relation does exist between the blood levels of mercury and diagnosis of an autism spectrum disorder. Moreover, the hair sample analysis results offer some support for the idea that persons with autism may be less efficient and more variable at eliminating mercury from the blood.”

Abstract

The question of what is leading to the apparent increase in autism is of great importance. Like the link between aspirin and heart attack, even a small effect can have major health implications. If there is any link between autism and mercury, it is absolutely crucial that the first reports of the question are not falsely stating that no link occurs. We have reanalyzed the data set originally reported by Ip et al. in 2004 and have found that the original p value was in error and that a significant relation does exist between the blood levels of mercury and diagnosis of an autism spectrum disorder. Moreover, the hair sample analysis results offer some support for the idea that persons with autism may be less efficient and more variable at eliminating mercury from the blood.

*

(( 13. )) Developmental Regression and Mitochondrial Dysfunction in a Child With Autism

Journal of Child Neurology / Volume 21, Number 2, February 2006

Jon S. Poling, MD, PhD, Department of Neurology and Neurosurgery

Johns Hopkins Hospital

This article showed that 38% of Kennedy Krieger Institute autism patients studied had one marker for impaired oxidative phosphorylation (mitochondrial dysfunction), and 47% had a second marker.

Excerpt: “Children who have (mitochondrial-related) dysfunctional cellular energy metabolism might be more prone to undergo autistic regression between 18 and 30 months of age if they also have infections or immunizations at the same time.”

*

(( 14. )) Oxidative Stress in Autism: Elevated Cerebellar 3-nitrotyrosine Levels

American Journal of Biochemistry and Biotechnology 4 (2): 73-84, 2008

Elizabeth M. Sajdel-Sulkowska, – Dept of Psychiatry, Harvard Medical School

Shows a potential link between mercury and the autopsied brains of young people with autism. A marker for oxidative stress was 68.9% higher in autistic brain issue than controls (a statistically significant result), while mercury levels were 68.2% higher.

Excerpt: The preliminary data suggest a need for more extensive studies of oxidative stress, its relationship to the environmental factors and its possible attenuation by antioxidants in autism.”

*

(( 15. )) Large Brains in Autism: The Challenge of Pervasive Abnormality

The Neuroscientist, Volume 11, Number 5, 2005.

Martha Herbert, MD, PhD, Harvard University

This study helps refute the notion that the brains of autistic children are simply wired differently and notes, “neuroinflammation appears to be present in autistic brain tissue from childhood through adulthood.” Dr. Herbert suggests that chronic disease or an external environmental source (like heavy metals) may be causing the inflammation.

Excerpt: “Oxidative stress, brain inflammation, and microgliosis have been much documented in association with toxic exposures including various heavy metals…the awareness that the brain as well as medical conditions of children with autism may be conditioned by chronic biomedical abnormalities such as inflammation opens the possibility that meaningful biomedical interventions may be possible well past the window of maximal neuroplasticity in early childhood because the basis for assuming that all deficits can be attributed to fixed early developmental alterations in neural architecture has now been undermined.”

Abstract

The most replicated finding in autism neuroanatomy—a tendency to unusually large brains—has seemed paradoxical in relation to the specificity of the abnormalities in three behavioral domains that define autism. We now know a range of things about this phenomenon, including that brains in autism have a growth spurt shortly after birth and then slow in growth a few short years afterward, that only younger but not older brains are larger in autism than in controls, that white matter contributes disproportionately to this volume increase and in a nonuniform pattern suggesting postnatal pathology, that functional connectivity among regions of autistic brains is diminished, and that neuroinflammation (including microgliosis and astrogliosis) appears to be present in autistic brain tissue from childhood through adulthood. Alongside these pervasive brain tissue and functional abnormalities, there have arisen theories of pervasive or widespread neural information processing or signal coordination abnormalities (such as weak central coherence, impaired complex processing, and underconnectivity), which are argued to underlie the specific observable behavioral features of autism. This convergence of findings and models suggests that a systems- and chronic disease–based reformulation of function and pathophysiology in autism needs to be considered, and it opens the possibility for new treatment targets.

*

(( 16. )) Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism

Journal of Toxicology and Environmental Health, Nov-Dec 2006.

Janet Kern, Anne Jones, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas,

Texas, USA

“This article discusses the evidence for the case that some children with autism may become autistic from neuronal cell death or brain damage sometime after birth as result of insult; and addresses the hypotheses that toxicity and oxidative stress may be a cause of neuronal insult in autism… the article discusses what may be happening over the course of development and the multiple factors that may interplay and make these children more vulnerable to toxicity, oxidative stress, and neuronal insult.”

Abstract

According to the Autism Society of America, autism is now considered to be an epidemic. The increase in the rate of autism revealed by epidemiological studies and government reports implicates the importance of external or environmental factors that may be changing. This article discusses the evidence for the case that some children with autism may become autistic from neuronal cell death or brain damage sometime after birth as result of insult; and addresses the hypotheses that toxicity and oxidative stress may be a cause of neuronal insult in autism. The article first describes the Purkinje cell loss found in

autism, Purkinje cell physiology and vulnerability, and the evidence for postnatal cell loss. Second, the article describes the increased brain volume in autism and how it may be related to the Purkinje cell loss. Third, the evidence for toxicity and oxidative

stress is covered and the possible involvement of glutathione is discussed. Finally, the article discusses what may be happening over the course of development and the multiple factors that may interplay and make these children more vulnerable to toxicity, oxidative stress, and neuronal insult.

*

((17. )) Oxidative Stress in Autism

Pathophysiology, 2006.

Abha Chauhan, Ved Chauhan

This study provides a helpful overview of the growing evidence supporting the link between oxidative stress and autism.

Excerpt: “Upon completion of this article, participants should be able to: 1. Be aware of laboratory and clinical evidence of greater oxidative stress in autism. 2. Understand how gut, brain, nutritional, and toxic status in autism are consistent with greater oxidative stress. 3. Describe how anti-oxidant nutrients are used in the contemporary treatment of autism.”

*

((18. )) Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors

Neurotoxicology, Jan 2005.

S. Jill James, PhD [University of Arkansas].

This recent study demonstrates that Thimerosal lowers or inhibits the body’s ability to produce Glutathione, an antioxidant and the body’s primary cellular-level defense against mercury.

Excerpt: “Thimerosal-induced cytotoxicity was associated with depletion of intracellular Glutathione in both cell lines…The potential effect of Glutathione or N-acetylcysteine against mercury toxicity warrants further research as possible adjunct therapy to individuals still receiving Thimerosal-containing vaccines.”

*

(( 19. )) Aluminum adjuvant linked to gulf war illness induces motor neuron death in mice

Neuromolecular Medicine, 2007

Christopher Shaw, Ph.D. [Department of Ophthalmology and Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada]

This study demonstrates the extreme toxicity of the aluminum adjuvant used as a preservative in vaccines.

Excerpt: “testing showed motor deficits in the aluminum treatment group that expressed as a progressive decrease in strength measured…Significant cognitive deficits in water-maze learning were observed in the combined aluminum and squalene group…Apoptotic neurons were identified in aluminum-injected animals that showed significantly increased activated caspase-3 labeling in lumbar spinal cord (255%) and primary motor cortex (192%) compared with the controls. Aluminum-treated groups also showed significant motor neuron loss (35%) and increased numbers of astrocytes (350%) in the lumbar spinal cord.

*

(( 20. )) Environmental mercury release, special education rates, and autism disorder: an ecological study of Texa

Health & Place, 2006

Raymond F. Palmer, University of Texas Health Science Center

This study demonstrated the correlation between environmental mercury and autism rates in Texas.

Excerpt: “On average, for each 1,000 lb of environmentally released mercury, there was a 43% increase in the rate of special education services and a 61% increase in the rate of autism. The association between environmentally released mercury and special education rates were fully mediated by increased autism rates. This ecological study suggests the need for further research regarding the association between environmentally released mercury and developmental disorders such as autism.”

*

(( 21. )) Autism Spectrum Disorders in Relation to Distribution of Hazardous Air Pollutants in the SF Bay Area

Environmental Health Perspectives – Vol. 114 No. 9, September, 2006

Gayle Windham, Div. of Environmental and Occupational Disease Control, California Department of Health Services

284 ASD children & 657 controls, born in 1994 in Bay Area, were assigned exposure levels by birth tract for 19 chemicals. Risks for autism were elevated by 50% in tracts with the highest chlorinated solvents and heavy metals. The highest risk compounds were mercury, cadmium, nickel, trichloroethylene, and vinyl chloride, and the risk from heavy metals was almost twice as high as solvents.

Excerpt: “Our results suggest a potential association between autism and estimated metal concentrations, and possibly solvents, in ambient air around the birth residence.”

*

(( 22. )) A Case Series of Children with Apparent Mercury Toxic Encephalopathies Manifesting with Clinical Symptoms of Regressive Autistic Disorder

Journal of Toxicology and Environmental Health, 2007

David A. Geier, Mark R. Geier

This study reviewed the case histories and medical profiles of nine autistic children and concluded that eight of the nine children were mercury toxic and this toxicity manifested itself in a manner consistent with Autism Spectrum Disorders.

Excerpt: “…these previously normally developing children suffered mercury toxic encephalopathies that manifested with clinical symptoms consistent with regressive ASDs. Evidence for mercury intoxication should be considered in the differential diagnosis as contributing to some regressive ASDs.”

Abstract

Impairments in social relatedness and communication, repetitive behaviors, and stereotypic abnormal movement patterns characterize autism spectrum disorders (ASDs). It is clear that while genetic factors are important to the pathogenesis of ASDs, mercury exposure can induce immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining or associated with ASDs. The Institutional Review Board of the Institute for Chronic Illnesses (Office for Human Research Protections, U.S. Department of Health and Human Services, IRB number IRB00005375) approved the present study. A case series of nine patients who presented to the Genetic Centers of America for a genetic/developmental evaluation are discussed. Eight of nine patients (one patient was found to have an ASD due to Rett’s syndrome) (a) had regressive ASDs; (b) had elevated levels of androgens; (c) excreted significant amounts of mercury post chelation challenge; (d) had biochemical evidence of decreased function in their glutathione pathways; (e) had no known significant mercury exposure except from Thimerosal- containing vaccines/Rho(D)-immune globulin preparations; and (f) had alternate causes for their regressive ASDs ruled out. There was a significant dose-response relationship between the severity of the regressive ASDs observed and the total mercury dose children received from Thimerosal-containing vaccines/Rho (D)- immune globulin preparations. Based upon differential diagnoses, 8 of 9 patients examined were exposed to significant mercury from Thimerosal-containing biologic/vaccine preparations during their fetal/infant developmental periods, and subsequently, between 12 and 24 mo of age, these previously normally developing children suffered mercury toxic encephalopathies that manifested with clinical symptoms consistent with regressive ASDs. Evidence for mercury intoxication should be considered in the differential diagnosis as contributing to some regressive ASDs.

*

(( 23. )) Attention-deficit hyperactivity disorder and blood mercury level: a case-control study in chinese children

Neuropediatrics, August 2006 – P.R. Kong [Department of Pediatrics and Adolescent Medicine, The University of Hong Kong].

This study demonstrates that blood mercury levels are higher for children with ADHD.

Excerpt: “There was significant difference in blood mercury levels between cases and controls, which persists after adjustment for age, gender and parental occupational status. The geometric mean blood mercury level was also significantly higher in children with inattentive and combined subtypes of ADHD. High blood mercury level was associated with ADHD. Whether the relationship is causal requires further studies.”

*

(( 24. )) The Changing Prevalence of Autism In California

Journal of Autism and Developmental Disorders, April 2003

Mark F. Blaxill, David S. Baskin, and Walter O. Spitzer

This study helps to refute the supposition made by some researchers that autism’s epidemic may only be due to “diagnostic substitution”.

Excerpt: “They have suggested that ‘diagnostic substitution’ accounts for an apparent increase in the incidence of autism in California that is not real. This hypothesized substitution is not supported by proper and detailed analyses of the California data.”

*

(( 25. )) Mitochondrial Energy-Deficient Endophenotype in Autism

American Journal of Biochemistry and Biotechnology 4 (2): 198-207, 2008

J. Jay Gargus and Faiqa Imtiaz

Department of Physiology and Biophysics and Department of Pediatrics, Section of Human Genetics, School of Medicine, University of California, Irvine, Arabian Diagnostics Laboratory, King Faisal Specialist Hospital and Research Centre

Abstract

While evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be involved in the etiology of this multifactorial disorder. Furthermore, recent studies have pointed to a subset of autism associated with the biochemical endophenotype of mitochondrial energy deficiency, identified as a subtle impairment in fat and carbohydrate oxidation. This phenotype is similar, but more subtle than those seen in classic mitochondrial defects. In some cases the beginnings of the genetic underpinnings of these mitochondrial defects are emerging, such as mild mitochondrial dysfunction and secondary carnitine deficiency observed in the subset of autistic patients with an inverted duplication of chromosome 15q11-q13. In addition, rare cases of familial autism associated with sudden infant death syndrome (SIDS) or associated with abnormalities in cellular calcium homeostasis, such as malignant hyperthermia or cardiac arrhythmia, are beginning to emerge. Such special cases suggest that the pathophysiology of autism may comprise pathways that are directly or indirectly involved in mitochondrial energy production and to further probe this connection three new avenues seem worthy of exploration: 1) metabolomic clinical studies provoking controlled aerobic exercise stress to expand the biochemical phenotype, 2) high-throughput expression arrays to directly survey activity of the genes underlying these biochemical pathways and 3) model systems, either based upon neuronal stem cells or model genetic organisms, to discover novel genetic and environmental inputs into these pathways.

*

(( 26. )) Bridging from Cells to Cognition in Autism Pathophysiology: Biological

Pathways to Defective Brain Function and Plasticity

American Journal of Biochemistry and Biotechnology 4 (2): 167-176, 2008

Matthew P. Anderson, Brian S. Hooker and Martha R. Herbert

Departments of Neurology and Pathology, Harvard Medical School/Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, High Throughput Biology Team, Fundamental Science Directorate, Pacific Northwest National Laboratory, Pediatric Neurology/Center for Morphometric Analysis, Massachusetts General Hospital/Harvard Medical School, and Center for Child and Adolescent Development, Cambridge Health Alliance/Harvard Medical School

Abstract: We review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative stressors persist beyond early development (with potential further exacerbations), producing ongoing functional consequences. In organs with a high metabolic demand such as the central nervous system, the continued use of mitochondria with damaged DNA and impaired metabolic enzyme function may generate additional ROS which will cause persistent activation of the innate immune system leading to more ROS production. Such a mechanism would self-sustain and possibly progressively worsen. The mitochondrial dysfunction and altered redox signal transduction pathways found in autism would conspire to activate both astroglia and microglia. These activated cells can then initiate a broad-spectrum proinflammatory gene response. Beyond the direct effects of ROS on neuronal function, receptors on neurons that bind the inflammatory mediators may serve to inhibit neuronal signaling to protect them from excitotoxic damage during various pathologic

insults (e.g., infection). In autism, over-zealous neuroinflammatory responses could not only influence neural developmental processes, but may more significantly impair neural signaling involved in cognition in an ongoing fashion. This model makes specific predictions in patients and experimental animal models and suggests a number of targets sites of intervention. Our model of potentially reversible pathophysiological mechanisms in autism motivates our hope that effective therapies may soon appear on the horizon.

*

(( 27. )) Heavy-Metal Toxicity—With Emphasis on Mercury

John Neustadt, ND, and Steve Pieczenik, MD, PhD

Research Review

Conclusion: Metals are ubiquitous in our environment, and exposure to them is inevitable. However, not all people accumulate toxic levels of metals or exhibit symptoms of metal toxicity, suggesting that genetics play a role in their potential to damage health. Metal toxicity creates multisystem dysfunction, which appears to be mediated primarily through mitochondrial damage from glutathione depletion.

Accurate screening can increase the likelihood that patients with potential metal toxicity are identified. The most accurate screening method for assessing chronic-metals exposure and metals load in the body is a provoked urine test.

*

(( 28. )) Evidence of Mitochondrial Dysfunction in Autism and Implications for Treatment

American Journal of Biochemistry and Biotechnology 4 (2): 208-217, 2008

Daniel A. Rossignol, J. Jeffrey Bradstreet, International Child Development Resource Center,

Abstract: Classical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. It is not associated with discernable mitochondrial pathology in muscle biopsy specimens despite objective evidence of lowered mitochondrial functioning. Exposure to environmental toxins is the likely etiology for MtD in autism. This dysfunction then contributes to a number of diagnostic symptoms and comorbidities observed in autism including: cognitive impairment, language deficits, abnormal energy metabolism, chronic gastrointestinal problems, abnormalities in fatty acid oxidation, and increased oxidative stress. MtD and oxidative stress may also explain the high male to female ratio found in autism due to increased male vulnerability to these dysfunctions.

Biomarkers for mitochondrial dysfunction have been identified, but seem widely under-utilized despite available therapeutic interventions. Nutritional supplementation to decrease oxidative stress along with factors to improve reduced glutathione, as well as hyperbaric oxygen therapy (HBOT) represent supported and rationale approaches. The underlying pathophysiology and autistic symptoms of affected individuals would be expected to either improve or cease worsening once effective treatment for MtD is implemented.

*

(( 29. )) Proximity to point sources of environmental mercury release as a predictor of autism prevalence

Health & Place, 2008

Raymond F. Palmer, Stephen Blanchard, Robert Wood

University of Texas Health Science Center, San Antonio Department of Family and Community Medicine, Our Lady of the Lake University, San Antonio Texas, Chair, Department of Sociology

This study should be viewed as hypothesis-generating – a first step in examining the potential role of environmental mercury and childhood developmental disorders. Nothing is known about specific exposure routes, dosage, timing, and individual susceptibility. We suspect that persistent low-dose exposures to various environmental toxicants, including mercury, that occur during critical windows of neural development among genetically susceptible children (with a diminished capacity for metabolizing accumulated toxicants) may increase the risk for developmental disorders such as autism. Successfully identifying the specific combination of environmental exposures and genetic susceptibilities can inform the development of targeted prevention intervention strategies.

*

(( 30. )) Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions

Developmental Medicine & Child Neurology, 2007

Guiomar Oliveira MD PhD, Centro de Desenvolvimento da Criança, Hospital Pediátrico de Coimbra; Assunção Ataíde BSc, Direcção Regional de Educação do Centro Coimbra;

Carla Marques MSc, Centro de Desenvolvimento da Criança, Hospital Pediátrico de Coimbra; Teresa S Miguel BSc, Direcção Regional de Educação do Centro, Coimbra;

Ana Margarida Coutinho BSc, Instituto Gulbenkian de Ciência, Oeiras; Luísa Mota-Vieira PhD, Unidade de Genética e Patologia moleculares, Hospital do Divino Espírito Santo, Ponta Delgada, Açores; Esmeralda Gonçalves PhD; Nazaré Mendes Lopes PhD, Faculdade de Ciências e Tecnologia, Universidade de Coimbra; Vitor Rodrigues MD PhD; Henrique Carmona da Mota MD PhD, Faculdade de Medicina, Universidade de Coimbra, Coimbra; Astrid Moura Vicente PhD, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

*Correspondence to first author at Hospital Pediátrico de Coimbra, Av Bissaya Barreto, 3000-076 Coimbra, Portugal. E-mail: guiomar@hpc.chc.min-saude.pt

Abstract: The objective of this study was to estimate the prevalence of autistic spectrum disorder (ASD) and identify its clinical characterization, and medical conditions in a paediatric population in Portugal. A school survey was conducted in elementary schools, targeting 332 808 school-aged children in the mainland and 10 910 in the Azores islands. Referred children were directly assessed using the Diagnostic and Statistical Manual of Mental Disorders (4th edn), the Autism Diagnostic Interview–Revised, and the Childhood Autism Rating Scale. Clinical history and a laboratory investigation was performed. In parallel, a systematic multi-source search of children known to have autism was carried out in a restricted region. The global prevalence of ASD per 10 000 was 9.2 in mainland, and 15.6 in the Azores, with intriguing regional differences. A diversity of associated medical conditions was documented in 20%, with an unexpectedly high rate of mitochondrial respiratory chain disorders.

Original Source: Lisa Joyce Goes – Facebook Notes

– Lisa Joyce Goes
Facebook Notes

[ SOURCE: Health Impact News ]

***